Drosophila Embryonic Cell-Cycle Mutants
نویسندگان
چکیده
منابع مشابه
Drosophila Embryonic Cell-Cycle Mutants
Nearly all cell division mutants in Drosophila were recovered in late larval/pupal lethal screens, with less than 10 embryonic lethal mutants identified, because larval development occurs without a requirement for cell division. Only cells in the nervous system and the imaginal cells that generate the adult body divide during larval stages, with larval tissues growing by increasing ploidy rathe...
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Two alleles of the Drosophila melanogaster Rfc4 (DmRfc4) gene, which encodes subunit 4 of the replication factor C (RFC) complex, cause striking defects in mitotic chromosome cohesion and condensation. These mutations produce larval phenotypes consistent with a role in DNA replication but also result in mitotic chromosomal defects appearing either as premature chromosome condensation-like or pr...
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We have cloned and characterized the ida gene that is required for proliferation of imaginal disc cells during Drosophila development. IDA is homologous to APC5, a subunit of the anaphase-promoting complex (APC/cyclosome). ida mRNA is detected in most cell types throughout development, but it accumulates to its highest levels during early embryogenesis. A maternal component of IDA is required f...
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In Drosophila, fertilization is required for the embryo to undergo the first 13 rapid cell cycles, which consist of alternating DNA replication and mitosis without gap phases. In contrast, eggs from females mutant in the pan gu (png) locus no longer require fertilization to initiate DNA replication, and both fertilized embryos and unfertilized eggs from png mutant mothers have giant polyploid n...
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Spindle alignment along the apicobasal polarity axis is mandatory for proper self-renewing asymmetric division in Drosophila neuroblasts (NBs). In embryonic NBs, spindles have been reported to assemble orthogonally to the polarity axis and later rotate to align with it. In larval NBs, spindles assemble directly aligned with the axis owing to the differential spatiotemporal control of the microt...
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ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2013
ISSN: 2160-1836
DOI: 10.1534/g3.113.007880